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When adults should get help for vomiting

Vomiting is on the GLP-1 labels. Most episodes pass. These are the general criteria for when to stop waiting, restated in our own words from MedlinePlus, plus what the medicine labels add.[19][1][2]

Call 911 (or your local emergency number) if:

  • •there is blood in the vomit, or it looks like dark coffee grounds
  • •you suspect something you swallowed was poisonous

Contact your clinician right away if:

  • 24 hthe vomiting has gone on for more than 24 hours
  • 12 hno drink has stayed down for 12 hours or more
  • 8 hyou have not passed urine for 8 hours or more
  • 3+you have thrown up 3 or more times within one day
  • •severe pain in your stomach area or belly
  • •a headache, or your neck feels stiff

The medicine labels add: call your clinician right away for severe belly pain that does not go away. It may spread to your back and can happen even without vomiting.[1][2] Also on the labels: yellow skin or eyes; a sudden change in vision.[1][2]

Dehydration from vomiting or diarrhea can harm the kidneys, which is why the labels warn about it.[1]

These are general criteria for adults, not a diagnosis and not specific to any one medicine. If you are unsure, call. Education, not medical advice.

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Questions to take to your prescriber

This site explains; it does not decide. These are the questions the chapter leaves you with.

  • Which side effects should I report right away, and which can wait for our next visit?
  • If I cannot keep fluids down, what should I do first, and who do I call after hours?
  • Do any of my other medicines make dehydration more of a concern for me?

Sources

Numbering matches the free handbook, so a source number on a page and in the PDF point to the same document. "Primary" means we read the original label or study; "secondary" means a report about it.

  1. health agency. MedlinePlus Medical Encyclopedia. Nausea and vomiting: when to contact a medical professional. https://medlineplus.gov/ency/article/003117.htm
  2. FDA label (primary). Wegovy (semaglutide) US prescribing information, revised 02/2026. Section 6.1, Table 3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/218316s004lbl.pdf
  3. FDA label (primary). Zepbound (tirzepatide) US prescribing information, revised 08/2026. Table 1. https://pi.lilly.com/us/zepbound-uspi.pdf